Abstract: MicroRNA-199a-3p (miR-199a-3p), a member of the miRNA family, serves as a critical regulator of gene expression and plays essential roles in cellular processes such as growth, apoptosis, invasion, migration, and metastasis. MiR-199a-3p is also present in human ocular tissues, including the aqueous humor, vitreous body, conjunctival epithelial cells, and cornea, where it exerts significant regulatory effects on the development and progression of retinal diseases. By modulating signaling pathways and interacting with specific target genes, miR-199a-3p induces upregulation or downregulation of their expression in retinal pathologies. This mechanism underscores its pivotal role in retinopathies such as diabetic retinopathy, age-related macular degeneration, and proliferative vitreoretinopathy.

Key words: Retinopathy, MicroRNA, MiR-199a-3p